Edaravone, a free radical scavenger, protects against retinal damage in vitro and in vivo.

@article{Inokuchi2009EdaravoneAF,
  title={Edaravone, a free radical scavenger, protects against retinal damage in vitro and in vivo.},
  author={Yuta Inokuchi and Shunsuke Imai and Yoshimi Nakajima and Masamitsu Shimazawa and Makoto Aihara and Makoto Araie and Hideaki Hara},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2009},
  volume={329 2},
  pages={687-98}
}
Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a free radical scavenger, is used for the treatment of acute cerebral infarction. In this study, we investigated whether edaravone is neuroprotective against retinal damage. In vitro, we used a radical-scavenging capacity assay using reactive oxygen species-sensitive probes to investigate the effects of edaravone on H(2)O(2), superoxide anion (O(2)*), and hydroxyl radical (*OH) production in a rat retinal ganglion cell line (RGC-5). The effect of… CONTINUE READING
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