Eczema and ceramides: an update

@article{Jungersted2013EczemaAC,
  title={Eczema and ceramides: an update},
  author={Jakob Mutanu Jungersted and Tove Agner},
  journal={Contact Dermatitis},
  year={2013},
  volume={69}
}
Although normal epidermal barrier function depends on numerous factors, including corneocytes, lipids, enzymes, pH, and calcium gradient, the key players are lipids and proteins in the stratum corneum. Atopic dermatitis is characterized by barrier abnormalities, such as the presence of filaggrin mutations in almost 50% of patients with moderate/severe atopic dermatitis, and lipid disturbances, mainly expressed as insufficient ceramides. In this review, with an emphasis on human studies, we… 
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