Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in a murine model

  title={Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in a murine model},
  author={Susan K. Halstead and Femke M. P. Zitman and Peter D Humphreys and Kay N. Greenshields and Jan J.G.M. Verschuuren and Bart Casper Jacobs and Russell P. Rother and Jaap J. Plomp and Hugh John Willison},
  journal={Brain : a journal of neurology},
  volume={131 Pt 5},
Anti-GQ1b ganglioside antibodies are the serological hallmark of the Miller Fisher syndrome (MFS) variant of the paralytic neuropathy, Guillain-Barré syndrome, and are believed to be the principal pathogenic mediators of the disease. In support of this, we previously showed in an in vitro mouse model of MFS that anti-GQ1b antibodies were able to bind and disrupt presynaptic motor nerve terminals at the neuromuscular junction (NMJ) as one of their target sites, thereby causing muscle paralysis… CONTINUE READING
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