Ectromelia virus encodes a BTB/kelch protein, EVM150, that inhibits NF-κB signaling.

  title={Ectromelia virus encodes a BTB/kelch protein, EVM150, that inhibits NF-κB signaling.},
  author={Qian Wang and Kristin Burles and Brianne A. Couturier and Crystal M H Randall and Joanna L Shisler and Michele Barry},
  journal={Journal of virology},
  volume={88 9},
UNLABELLED The NF-κB signaling pathway plays a critical role in inflammation and innate immunity. Consequently, many viruses have evolved strategies to inhibit NF-κB in order to facilitate replication and evasion of the host immune response. Recently, we determined that ectromelia virus, the causative agent of mousepox, contains a family of four BTB/kelch proteins that interact with cullin-3-based ubiquitin ligases. We demonstrate here that expression of EVM150, one of the four BTB/kelch… CONTINUE READING
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