Ectopic notch activation in developing podocytes causes glomerulosclerosis.

@article{Waters2008EctopicNA,
  title={Ectopic notch activation in developing podocytes causes glomerulosclerosis.},
  author={Aoife M. Waters and Megan Yi Jun Wu and Tuncer Onay and Jacob Scutaru and Ju Liu and Corrinne G. Lobe and Susan E Quaggin and Tino D. Piscione},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2008},
  volume={19 6},
  pages={1139-57}
}
Genetic evidence supports an early role for Notch signaling in the fate of podocytes during glomerular development. Decreased expression of Notch transcriptional targets in developing podocytes after the determination of cell fate suggests that constitutive Notch signaling may oppose podocyte differentiation. This study determined the effects of constitutive Notch signaling on podocyte differentiation by ectopically expressing Notch's intracellular domain (NOTCH-IC), the biologically active… CONTINUE READING
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BASIC RESEARCH www.jasn.org 1156 Journal of the American Society of Nephrology

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