Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia.

  title={Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia.},
  author={Douglas K. Graham and Dana B Salzberg and Joanne Kurtzberg and Susan Sather and Glenn K. Matsushima and Amy K. Keating and Xiayuan Liang and Mark A Lovell and Sara A Williams and Thomas L. Dawson and Michael J. Schell and Adil A Anwar and H. Ralph Snodgrass and H. Shelton Earp},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={12 9},
PURPOSE The Mer receptor tyrosine kinase, cloned from a B-lymphoblastoid library, is the mammalian orthologue of the chicken retroviral oncogene v-eyk and sends antiapoptotic and transforming signals when activated. To determine if Mer expression is ectopic in T-cell acute lymphoblastic leukemia (ALL) and potentially important in leukemogenesis, we analyzed Mer expression in normal human thymocytes and lymphocytes and in pediatric ALL patient samples. EXPERIMENTAL DESIGN Reverse transcription… CONTINUE READING
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