Ectopic expression of systemic RNA interference defective protein in embryonic stem cells.

@article{Tsang2007EctopicEO,
  title={Ectopic expression of systemic RNA interference defective protein in embryonic stem cells.},
  author={Suk Ying Tsang and Jennifer C. Moore and Rika Van Huizen and Camie W Y Chan and Ronald A. Li},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={357 2},
  pages={480-6}
}
RNA interference (RNAi), a post-transcriptional gene silencing mechanism originally described in Caenorhabditis elegans, involves sequence-specific mRNA degradation mediated by double-stranded RNAs (dsRNAs). Passive dsRNA uptake has been uniquely observed in C. elegans due to the expression of systemic RNA interference defective-1 (SID-1). Here we investigated the ability of ectopic SID-1 expression to enable passive cellular uptake of short interfering RNA (siRNA) or double stranded RNA (dsRNA… CONTINUE READING
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