Ectopic expression of protein-tyrosine kinase Bcr-Abl suppresses tumor necrosis factor (TNF)-induced NF-kappa B activation and IkappaBalpha phosphorylation. Relationship with down-regulation of TNF receptors.

@article{Mukhopadhyay2002EctopicEO,
  title={Ectopic expression of protein-tyrosine kinase Bcr-Abl suppresses tumor necrosis factor (TNF)-induced NF-kappa B activation and IkappaBalpha phosphorylation. Relationship with down-regulation of TNF receptors.},
  author={Asok Mukhopadhyay and Shishir Shishodia and J. Timothy Suttles and Katherine C. Brittingham and Betty Lamothe and Ramdevi Nimmanapalli and Kapil N. Bhalla and Bharat Bhushan Aggarwal},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 34},
  pages={30622-8}
}
Bcr-Abl, the product of the protooncogene bcr-abl, is a constitutively active protein-tyrosine kinase that is highly expressed in chronic myelogenous leukemia and in acute myeloid leukemia cells. Because Bcr-Abl is known to provide mitogenic signals through suppression of apoptosis, we investigated the effect of this oncogene product on signaling by tumor necrosis factor (TNF), a proapoptotic cytokine. We used a bcr-abl-deficient human megakaryocytic leukemia cell line MO7E and an isogenic MBA… CONTINUE READING

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