Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated.

@article{Villaseor2008EctopicEO,
  title={Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated.},
  author={Jennifer Villase{\~n}or and Whitney Besse and Christophe Benoist and Diane Mathis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 41},
  pages={15854-9}
}
Thymic medullary epithelial cells (MECs) express a broad repertoire of peripheral-tissue antigens (PTAs), many of which depend on the transcriptional regulatory factor Aire. Although Aire is known to be critically important for shaping a self-tolerant T cell repertoire, its role in MEC maturation and function remains poorly understood. Using a highly sensitive and reproducible single-cell PCR assay, we demonstrate that individual Aire-expressing MECs transcribe a subset of PTA genes in a… CONTINUE READING