Ectopic expression of fatty acid-binding protein 4 in the glomerulus is associated with proteinuria and renal dysfunction.

@article{Tanaka2014EctopicEO,
  title={Ectopic expression of fatty acid-binding protein 4 in the glomerulus is associated with proteinuria and renal dysfunction.},
  author={Marenao Tanaka and Masato Furuhashi and Yusuke Okazaki and Tomohiro Mita and Takahiro Fuseya and Kohei Ohno and Shutaro Ishimura and Hideaki Yoshida and Tetsuji Miura},
  journal={Nephron. Clinical practice},
  year={2014},
  volume={128 3-4},
  pages={345-51}
}
BACKGROUND/AIMS Fatty acid-binding proteins (FABPs) are a family of intracellular lipid chaperones. Among FABPs, FABP1 (liver FABP) is expressed in proximal tubular epithelial cells in the kidney, and urinary FABP1 has been reported to reflect damage of proximal tubular epithelial cells. However, roles of other FABP isoforms in renal pathologies have not been reported. Recently, FABP4 (adipocyte FABP/aP2) was reported to be expressed in peritubular capillaries (PTCs), but not in glomerular… CONTINUE READING

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