Ectopic expression of alkaline phosphatase in proximal tubular brush border membrane of human renal cell carcinoma.

@article{Prasad2005EctopicEO,
  title={Ectopic expression of alkaline phosphatase in proximal tubular brush border membrane of human renal cell carcinoma.},
  author={Rajendra Prasad and Shahid Lambe and Pawan Kaler and Shailja Pathania and Sukhdeep Kumar and Savita Verma Attri and Sunil Kumar Singh},
  journal={Biochimica et biophysica acta},
  year={2005},
  volume={1741 3},
  pages={240-5}
}
The present study was conducted to find out any alteration in the expression and activity of alkaline phosphatase in the brush border membrane (BBM) from renal cell carcinoma (RCC) in comparison to normal renal BBM. The specific activity of alkaline phosphatase was drastically reduced in homogenate as well as BBM from RCC kidney when compared to ALP activity in BBM of normal kidney. Kinetic studies revealed that diminished activity of alkaline phosphatase in BBM isolated from RCC was… CONTINUE READING
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