Ectopic expression of Olig1 promotes oligodendrocyte formation and reduces neuronal survival in developing mouse cortex

In the cerebral cortex of the developing murine central nervous system, formation of neurons and astrocytes can be modulated by transcription factors with basic helix-loop-helix (bHLH) domains. However, transcription factors that promote formation of oligodendrocytes have yet to be identified. We show here that ectopic expression of the bHLH gene Olig1… CONTINUE READING