Ectopic expression of Msx-2 in posterior limb bud mesoderm impairs limb morphogenesis while inducing BMP-4 expression, inhibiting cell proliferation, and promoting apoptosis.

@article{Ferrari1998EctopicEO,
  title={Ectopic expression of Msx-2 in posterior limb bud mesoderm impairs limb morphogenesis while inducing BMP-4 expression, inhibiting cell proliferation, and promoting apoptosis.},
  author={Deborah Ferrari and Alexander C. Lichtler and Zhizhong Z Pan and Caroline N Dealy and William B. Upholt and Robert A. Kosher},
  journal={Developmental biology},
  year={1998},
  volume={197 1},
  pages={12-24}
}
During early stages of chick limb development, the homeobox-containing gene Msx-2 is expressed in the mesoderm at the anterior margin of the limb bud and in a discrete group of mesodermal cells at the midproximal posterior margin. These domains of Msx-2 expression roughly demarcate the anterior and posterior boundaries of the progress zone, the highly proliferating posterior mesodermal cells underneath the apical ectodermal ridge (AER) that give rise to the skeletal elements of the limb and… CONTINUE READING
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