Ectopic expression of Hoxa-1 in the zebrafish alters the fate of the mandibular arch neural crest and phenocopies a retinoic acid-induced phenotype.

@article{Alexandre1996EctopicEO,
  title={Ectopic expression of Hoxa-1 in the zebrafish alters the fate of the mandibular arch neural crest and phenocopies a retinoic acid-induced phenotype.},
  author={Daniel Alexandre and Jonathan Clarke and Elli Oxtoby and Y. L. Yan and T. Jowett and Nigel Holder},
  journal={Development},
  year={1996},
  volume={122 3},
  pages={735-46}
}
Considerable evidence has demonstrated that retinoic acid influences the formation of the primary body axis in vertebrates and that this may occur through the regulation of Hox gene expression. In this study, we show that the phenotype induced by exogenous retinoic acid in the zebrafish can also be generated by the overexpression of Hoxa-1 following injection of synthetic RNA into the fertilised egg. The isolation, sequence and expression pattern of the zebrafish Hoxa-1 gene is described. We… CONTINUE READING

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