Ectopic discharges trigger sympathetic sprouting in rat dorsal root ganglia following peripheral nerve injury

@article{Dong2002EctopicDT,
  title={Ectopic discharges trigger sympathetic sprouting in rat dorsal root ganglia following peripheral nerve injury},
  author={Chenghai Dong and Zuolei Xie and Jiyun Fan and Yikuan Xie},
  journal={Science in China Series C: Life Sciences},
  year={2002},
  volume={45},
  pages={191-200}
}
Experimental backgrounds of ectopic discharges were made by i.p. administrating of 4-aninopyriding (4-AP), a K+ channel blocker, or anisodamine, a muscarinic receptor blocker, in CCI rats, and the sympathetic sprouting in the dorsal root ganglia (DRG) as well as the heat-hyperalgesia was observed. It was demonstrated that the increased ectopic discharges induced by 4-AP promote sympathetic sprouting in the DRG and a greater number of sympathetic basket cells were developed, causing exacerbation… CONTINUE READING