Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain.

@article{Busser1998EctopicCC,
  title={Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain.},
  author={Jonathan C. Busser and David S. Geldmacher and Karl Herrup},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 8},
  pages={2801-7}
}
Alzheimer's disease (AD) is a major dementing illness characterized by regional concentrations of senile plaques, neurofibrillary tangles, and extensive neuronal cell death. Although cell and synaptic loss is most directly linked to the severity of symptoms, the mechanisms leading to the neuronal death remain unclear. Based on evidence linking neuronal death during development to unexpected reappearance of cell cycle events, we investigated the brains of 12 neuropathologically verified cases of… CONTINUE READING
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