Ectopic beats and atrioventricular conduction disturbances. In patients with hypopotassemia.

  title={Ectopic beats and atrioventricular conduction disturbances. In patients with hypopotassemia.},
  author={Sidney Davidson and Borys Surawicz},
  journal={Archives of internal medicine},
  volume={120 3},
PERFUSION with potassium deficient solutions induces ectopic rhythms and atrioventricular (AV) conduction disturbances in isolated rabbit hearts. 1,2 In dogs and in man, potassium loss sensitizes the heart to digitalis intoxication which is manifested by ectopic beats, ectopic rhythms and AV conduction disturbances. 3 Levine 4 suggested that potassium loss may precipitate various arrhythmias, particularly supraventricular tachycardia, in patients receiving and in patients not receiving… 
Bartter ' s syndrome . frequency of arrhythmias in Electrocardiographic findings and
Dangerous tachycardia was rare in these patients with chronic potassium deficiency caused by Bartter's syndrome, and the general pattern of slight electrocardiographic changes may reflect an adaptation of the myocardium to hypokalaemia.
Diuretic-induced ventricular ectopic activity.
Electrolyte abnormalities underlying lethal and ventricular arrhythmias.
It is well known that changes in serum potassium cause ventricular arrhythmias as a result of clearly documented changes in the electrophysiological characteristics of single fibers. Hypopotassemia
Electrocardiographic findings and frequency of arrhythmias in Bartter's syndrome.
Dangerous tachycardia was rare in these patients with chronic potassium deficiency caused by Bartter's syndrome and the general pattern of slight electrocardiographic changes may reflect an adaptation of the myocardium to hypokalaemia.
Arrhythmogenic potential of diuretic induced hypokalaemia in patients with mild hypertension and ischaemic heart disease.
It is concluded that minor changes in plasma potassium concentration are associated with increased ventricular electrical instability in patients with ischaemic heart disease and mild hypokalaemia in such patients may predispose to life threatening arrhythmias and should be avoided.
Diuretic-induced hypokalaemia and surgery: much ado about nothing?
It has been calculated that a controlled study of 8,600 patients would be needed to detect a 50% increase in mortality due to intraoperative arrhythmias attributable to hypokalaemia, and it has never been clearly demonstrated that diuretic-induced hypokalemia, per se, increases the risk of clinically important arrhythias.
Thiazide-induced hypokalemia with associated major ventricular arrhythmias. Report of a case and comment on therapeutic use of bretylium.
Treatment with bretylium tosylate appears to be a new and effective agent for the control of major ventricular arrhythmias.
The Overstated Risk of Preoperative Hypokalemia
The data fail to support the common practice of delaying operation for acute potassium replacement in patients whose preoperative serum potassium is less than normal, even in the presence of cardiovascular disease.
Effects of hypokalemia on the various parts of the conduction system of the dog heart in situ
Effective refractory period (ERP) of atrial muscle, initially the longest in ERPs of conduction system in vagotomized animals, was shortened by about 20% and the mechanism of all these alterations is discussed.


Role of electrolytes in etiology and management of cardiac arrhythmias.
  • B. Surawicz
  • Medicine
    Progress in cardiovascular diseases
  • 1966
Unusual effects of potassium deficiency on the heart of a child with cystinosis.
The authors suggest that the sudden death of children with cystinosis during intravenous administration of glucose is caused by cardiac effects of potassium deficiency, possibly of the type presented in this case.
Effect of potassium and calcium deficiency on the monophasic action potential, electrocardiogram and contractility of isolated rabbit hearts.
Isolated rabbit hearts were perfused with Krebs-Henseleit solution deficient in K, Ca or both. Ventricular monophasic action potentials registered with the suction electrode, electrocardiograms and
Decrease in serum potassium concentrations and appearance of cardiac arrhythmias during infusion of potassium with glucose in potassium-depleted patients.
This study was prompted by the appearance of serious ventricular arrhythmias in 2 hypopotassemic patients during the intravenous infusion of a solution of potassium chloride with glucose, which critically altered the potassium gradient across myocardial cell membranes, precipitating grave manifestations of cardiotoxicity.
Quantitative Analysis of the Electrocardiographic Pattern of Hypopotassemia
Electrocardiographic patterns typical of hypopotassemia and compatible with hypopotassemia were defined on the basis of the number of electrocardiographic signs of hypopotassemia present in 2 leads
Effect of high K, low K, and quinidine on QRS duration and ventricular action potential
Perfusion of isolated rabbit hearts with high potassium, low potassium, and quinidine solutions caused a diffuse widening of the QRS complex with no change in shape. These QRS changes were correlat...
Arrhythmias and potassium in man.
  • A. Pick
  • Medicine
    American heart journal
  • 1966