Ectopic T Cell Receptor-α Locus Control Region Activity in B Cells Is Suppressed by Direct Linkage to Two Flanking Genes at Once

@inproceedings{Knirr2010EctopicTC,
  title={Ectopic T Cell Receptor-α Locus Control Region Activity in B Cells Is Suppressed by Direct Linkage to Two Flanking Genes at Once},
  author={Stefan Knirr and Janette Gomos-Klein and Blanca E. Andino and Faith Harrow and Karl F. Erhard and Damian Kovalovsky and Derek B Sant'Angelo and Benjamin D. Ortiz},
  booktitle={PloS one},
  year={2010}
}
The molecular mechanisms regulating the activity of the TCRα gene are required for the production of the circulating T cell repertoire. Elements of the mouse TCRα locus control region (LCR) play a role in these processes. We previously reported that TCRα LCR DNA supports a gene expression pattern that mimics proper thymus-stage, TCRα gene-like developmental regulation. It also produces transcription of linked reporter genes in peripheral T cells. However, TCRα LCR-driven transgenes display… CONTINUE READING
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