Ectopic PDX-1 expression in liver ameliorates type 1 diabetes.

  title={Ectopic PDX-1 expression in liver ameliorates type 1 diabetes.},
  author={Keren Shternhall-Ron and Francisco J. Quintana and Shira Y. Perl and Irit Meivar-Levy and Iris Barshack and Irun R. Cohen and Sarah Ferber},
  journal={Journal of autoimmunity},
  volume={28 2-3},
Type 1 diabetes mellitus (T1DM) results from a specific autoimmune mediated destruction of the pancreatic beta-cells. PDX-1 induced developmentally redirected liver cells were suggested to restore the ablated pancreatic function in chemically induced diabetes. However, developmentally redirected liver cells, may have acquired along with the desired beta-cell characteristics and functions, also undesired sensitivity to autoimmune attack and therefore may be inefficient in ameliorating T1DM. This… CONTINUE READING
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