Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-{alpha} on Fanconi anemia hematopoietic stem and progenitor cells.

@article{Milsom2009EctopicHO,
  title={Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-\{alpha\} on Fanconi anemia hematopoietic stem and progenitor cells.},
  author={Michael D Milsom and Bernhard Schiedlmeier and Jeff Bailey and Mi-Ok Kim and Dandan Li and Michael Jansen and Abdullah Mahmood Ali and Michelle Rene Kirby and Christopher Baum and Leslie J. Fairbairn and David A Williams},
  journal={Blood},
  year={2009},
  volume={113 21},
  pages={5111-20}
}
Ectopic delivery of HOXB4 elicits the expansion of engrafting hematopoietic stem cells (HSCs). We hypothesized that inhibition of tumor necrosis factor-alpha (TNF-alpha) signaling may be central to the self-renewal signature of HOXB4. Because HSCs derived from Fanconi anemia (FA) knockout mice are hypersensitive to TNF-alpha, we studied Fancc(-/-) HSCs to determine the physiologic effects of HOXB4 on TNF-alpha sensitivity and the relationship of these effects to the engraftment defect of FA… CONTINUE READING
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