Ectopic Expression of the Ets Transcription Factor ER81 in Transgenic Mouse Mammary Gland Enhances Both Urokinase Plasminogen Activator and Stromelysin-1 Transcription

The PEA3 group members PEA3, ER81 and ERM, which are highly conserved transcription factors from the Ets family, are over-expressed in metastatic mammary tumors. In the current study, we present the characterization of a transgenic mouse strain which over-expresses ER81 in the mammary gland via the long terminal repeat of the mouse mammary tumor virus (LTR… CONTINUE READING