Ectopic Expression of MAFB Gene in Human Myeloma Cells Carrying (14;20)(q32;q11) Chromosomal Translocations

@inproceedings{Hanamura2001EctopicEO,
  title={Ectopic Expression of MAFB Gene in Human Myeloma Cells Carrying (14;20)(q32;q11) Chromosomal Translocations},
  author={Ichiro Hanamura and Shinsuke Iida and Yumiko Akano and Yoshihito Hayami and Miyuki Kato and Kazuhisa Miura and Shinsuke Harada and Shogo Banno and Atsushi Wakita and Hitoshi Kiyoi and Tomoki Naoe and Shiro Shimizu and Shin‐ichi Sonta and Masakazu Nitta and Masafumi Taniwaki and Ryuzo Ueda},
  booktitle={Japanese journal of cancer research : Gann},
  year={2001}
}
Chromosome 14q +, which represents a chromosomal rearrangement involving the immunoglobulin heavy chain gene (IgH) locus, is a genetic hallmark of human multiple myeloma (MM). Here, we report the identification of (14;20)(q32;q11) chromosomal translocations found in MM cells. Double color fluorescence in situ hybridization analyses pinpointed the breakpoints at the 20q11 locus in two MM cell lines within a length of at most 680 kb between the KIAA0823 and MAFB gene loci. Among the transcribed… CONTINUE READING

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