Ectopic Expression of CXCR5/BLR1 Accelerates Retinoic Acid- and Vitamin D3-Induced Monocytic Differentiation of U937 Cells

@article{Battle2002EctopicEO,
  title={Ectopic Expression of CXCR5/BLR1 Accelerates Retinoic Acid- and Vitamin D3-Induced Monocytic Differentiation of U937 Cells},
  author={T. Battle and A. Yen},
  journal={Experimental Biology and Medicine},
  year={2002},
  volume={227},
  pages={753 - 762}
}
  • T. Battle, A. Yen
  • Published 2002
  • Biology, Medicine
  • Experimental Biology and Medicine
The product of the blr1 gene is a CXC chemokine receptor (CXCR5) that regulates B lymphocyte migration and has been implicated in myelomonocytic differentiation. The U937 human leukemia cell line was used to study the role of blr1 in retinoic acid-regulated monocytic leukemia cell growth and differentiation. blr1 mRNA expression was induced within 12 hr by retinoic acid in U937 cells. To determine whether the early induction of blr1 might regulate inducible monocytic cell differentiation, U937… Expand

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