Ectopic β-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis

@article{Martinez2003EctopicO,
  title={Ectopic $\beta$-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis},
  author={Laurent O. Martinez and S{\'e}bastien Jacquet and J. P. Est{\`e}ve and Corinne Rolland and Elena Cabezon and Eric Champagne and Thierry Pineau and V. M. Georgeaud and John E. Walker and François Tercé and Xavier Collet and Bertrand Perret and Ronald Barbaras},
  journal={Nature},
  year={2003},
  volume={421},
  pages={75-79}
}
The effect of high-density lipoprotein (HDL) in protecting against atherosclerosis is usually attributed to its role in ‘reverse cholesterol transport. [] Key Result Here we show that this receptor is identical to the β-chain of ATP synthase, a principal protein complex of the mitochondrial inner membrane. Different experimental approaches confirm this ectopic localization of components of the ATP synthase complex and the presence of ATP hydrolase activity at the hepatocyte cell surface.
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