Ectoenzymes control adenosine modulation of immunoisolated cholinergic synapses

@article{Richardson1987EctoenzymesCA,
  title={Ectoenzymes control adenosine modulation of immunoisolated cholinergic synapses},
  author={Peter J. Richardson and Susan J. Brown and E. M. Bailyes and J Paul Luzio},
  journal={Nature},
  year={1987},
  volume={327},
  pages={232-234}
}
One of the most important inhibitory modulators of synaptic transmission in mammalian brain is adenosine. At some cholinergic terminals, adenosine is known to inhibit further release of acetyl-choline. It is unclear whether adenosine is released directly at the synapse or whether ATP is co-released with transmitter and hydro-lysed to adenosine in the synaptic cleft1–4. Methods used in the past for isolating nerve terminals have not yielded homogeneous preparations, making it impossible to… CONTINUE READING