Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling.

@article{Hr2012EctodysplasinRA,
  title={Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling.},
  author={Otso H{\"a}{\"a}r{\"a} and Enni Harjunmaa and P{\"a}ivi H. Lindfors and Sung-Ho Huh and Ingrid Fliniaux and Thomas {\AA}berg and Jukka Jernvall and David M Ornitz and Marja L Mikkola and Irma Thesleff},
  journal={Development},
  year={2012},
  volume={139 17},
  pages={3189-99}
}
Uncovering the origin and nature of phenotypic variation within species is the first step in understanding variation between species. Mouse models with altered activities of crucial signal pathways have highlighted many important genes and signal networks regulating the morphogenesis of complex structures, such as teeth. The detailed analyses of these models have indicated that the balanced actions of a few pathways regulating cell behavior modulate the shape and number of teeth. Currently… CONTINUE READING

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