Ectodysplasin A (EDA) - EDA receptor signalling and its pharmacological modulation.

  title={Ectodysplasin A (EDA) - EDA receptor signalling and its pharmacological modulation.},
  author={Christine Kowalczyk-Quintas and Pascal Schneider},
  journal={Cytokine & growth factor reviews},
  volume={25 2},
The TNF family ligand ectodysplasin A (EDA) regulates the induction, morphogenesis and/or maintenance of skin-derived structures such as teeth, hair, sweat glands and several other glands. Deficiencies in the EDA - EDA receptor (EDAR) signalling pathway cause hypohidrotic ectodermal dysplasia (HED). This syndrome is characterized by the absence or malformation of several skin-derived appendages resulting in hypotrychosis, hypodontia, heat-intolerance, dry skin and dry eyes, susceptibility to… CONTINUE READING
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