Ectodomain shedding and generation of two carboxy-terminal fragments of human complement receptor 2/CD21.

@article{Hoefer2009EctodomainSA,
  title={Ectodomain shedding and generation of two carboxy-terminal fragments of human complement receptor 2/CD21.},
  author={Melanie Merja Hoefer and Harald Illges},
  journal={Molecular immunology},
  year={2009},
  volume={46 13},
  pages={2630-9}
}
Numerous cell surface proteins are functionally regulated by a proteolytic cleavage event termed 'ectodomain shedding'. The complement receptor 2/CD21 extracellular domain (ectodomain) is constitutively released as a soluble form (sCD21), but its liberation can also be induced by various physiological and pharmacological stimuli. CD21-shedding modulates B cell activation, and sCD21 can activate other immune cells and allows transfer of immune complexes from marginal zone B cells to follicular… CONTINUE READING