Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge.

Abstract

The formation of the apical ectodermal ridge (AER) is critical for the distal outgrowth and patterning of the vertebrate limb. Recent work in the chick has demonstrated that interplay between the Wnt and Fgf signaling pathways is essential in the limb mesenchyme and ectoderm in the establishment and perhaps the maintenance of the AER. In the mouse, whereas… (More)

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@article{Barrow2003EctodermalWS, title={Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge.}, author={Jeffery R. Barrow and Kirk Thomas and Oreda Boussadia-Zahui and Robert Moore and Rolf Kemler and Mario R. Capecchi and Andrew P. McMahon}, journal={Genes & development}, year={2003}, volume={17 3}, pages={394-409} }