Ectodermal Factor Restricts Mesoderm Differentiation by Inhibiting p53

@article{Sasai2008EctodermalFR,
  title={Ectodermal Factor Restricts Mesoderm Differentiation by Inhibiting p53},
  author={Noriaki Sasai and Rieko Yakura and Daisuke Kamiya and Yoko Nakazawa and Yoshiki Sasai},
  journal={Cell},
  year={2008},
  volume={133},
  pages={878-890}
}
During gastrulation of the amphibian embryo, specification of the three germ layers, endo-, ecto-, and mesoderm, is regulated by maternal and zygotic mechanisms. Although it is known that mesoderm specification requires the cooperation between TGF-beta signaling and p53 activity and requires maternal factors, essential zygotic factors have been elusive… CONTINUE READING