Ectoderm as a determinant of early tissue pattern in the limb bud.


This review considers the hypothesis that the limb bud ectoderm establishes the initial pattern of the various mesodermal components within the limb bud. The evidence reviewed supports the hypothesis that the ectoderm establishes a peripheral, non-chondrogenic, avascular sleeve around the limb bud. The ectodermal influence is a diffusible factor that acts… (More)


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