Ecto-enzyme and signaling functions of lymphocyte CD73.

  title={Ecto-enzyme and signaling functions of lymphocyte CD73.},
  author={Regina Resta and Yoshihiro Yamashita and Linda F. Thompson},
  journal={Immunological reviews},
CD73 or ecto-5'-nucleotidase (5'-NT) is a widely expressed ecto-enzyme which catalyzes the dephosphorylation of AMP and other nucleoside monophosphates. CD73 participates in purine salvage through this enzymatic activity, supplying cells with precursors for energy metabolism and nucleic acid biosynthesis. As an enzyme that produces adenosine, CD73 can also regulate adenosine receptor engagement in many tissues. However, CD73 also has functions independent of its enzyme activity. Like many… CONTINUE READING


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