Ecstasy induces apoptosis via 5-HT(2A)-receptor stimulation in cortical neurons.

@article{Capela2007EcstasyIA,
  title={Ecstasy induces apoptosis via 5-HT(2A)-receptor stimulation in cortical neurons.},
  author={J P Capela and Eduarda Fernandes and Fernando Remi{\~a}o and Maria de Lourdes Bastos and Andreas Meisel and Fabricio E. L. Carvalho},
  journal={Neurotoxicology},
  year={2007},
  volume={28 4},
  pages={
          868-75
        }
}
3,4-Methylenedioxymethamphetamine (MDMA or "Ecstasy") is a psychoactive and hallucinogenic drug of abuse. MDMA has been shown to produce neurotoxicity both in animals and humans. MDMA and other amphetamines induce serotonergic and dopaminergic terminal neurotoxicity and also neurodegeneration in areas including the cortex, hippocampus, striatum and thalamus. Herein, we investigated the mechanisms involved in MDMA-induced neurotoxicity to neuronal serum free cultures from rat cortex. The… CONTINUE READING
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