Ecotin modulates thrombin activity through exosite-2 interactions.

  title={Ecotin modulates thrombin activity through exosite-2 interactions.},
  author={Helena Carla Rangel Castro and Robson de Queiroz Monteiro and Mariane Assafim and Nat{\'a}lia Izabel Loureiro and Charles S. Craik and Russolina B Zingali},
  journal={The international journal of biochemistry & cell biology},
  volume={38 11},
Ecotin is a Escherichia coli-derived protein that has been characterized as a potent inhibitor of serine-proteases. This protein is highly effective against several mammalian enzymes, which includes pancreatic and neutrophil-derived elastases, chymotrypsin, trypsin, factor Xa, and kallikrein. In this work we showed that ecotin binds to human alpha-thrombin… CONTINUE READING