Economical LD50 and slope determinations.

Abstract

Many regulatory standards and guidelines required LD50 determinations and dose-response curve slopes, using at least 5 animals per sex per dosage level and at least 3 levels. In contrast, the current trend is to use as few animals as necessary for toxicological studies. The moving average method for calculation of the LD50 has been available since 1947 but… (More)

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@article{Weil1983EconomicalLA, title={Economical LD50 and slope determinations.}, author={Carrol S. Weil}, journal={Drug and chemical toxicology}, year={1983}, volume={6 6}, pages={595-603} }