Economical LD50 and slope determinations.


Many regulatory standards and guidelines required LD50 determinations and dose-response curve slopes, using at least 5 animals per sex per dosage level and at least 3 levels. In contrast, the current trend is to use as few animals as necessary for toxicological studies. The moving average method for calculation of the LD50 has been available since 1947 but… (More)


Cite this paper

@article{Weil1983EconomicalLA, title={Economical LD50 and slope determinations.}, author={Carrol S. Weil}, journal={Drug and chemical toxicology}, year={1983}, volume={6 6}, pages={595-603} }