Economic and quality of life outcomes of antiretroviral therapy for HIV/AIDS in developing countries: a systematic literature review

  title={Economic and quality of life outcomes of antiretroviral therapy for HIV/AIDS in developing countries: a systematic literature review},
  author={Jennifer Beard and Frank G. Feeley and Sydney Rosen},
  journal={AIDS Care},
  pages={1343 - 1356}
Abstract The impacts of antiretroviral therapy (ART) on quality of life, mental health, labor productivity, and economic wellbeing for people living with HIV/AIDS in developing countries are only beginning to be measured. We conducted a systematic literature review to analyze the effect of ART on these economic and quality of life indicators in developing countries and assess the state of research on these topics. We searched Ovid/Medline, PubMed, Psych Info, Web of Science, Google Scholar, and… 
Economic Outcomes of Patients Receiving Antiretroviral Therapy for HIV/AIDS in South Africa Are Sustained through Three Years on Treatment
Some of the positive economic and social externalities anticipated as a result of large-scale treatment provision, such as increases in workforce participation and productivity and the ability of patients to carry on normal lives, may indeed be accruing.
The Impact of ART on the Economic Outcomes of People Living with HIV/AIDS
ART was associated with greater improvement in work status, even after controlling for change in physical health functioning, suggesting other factors associated with ART may influence work.
Quality of Life Outcomes of Antiretroviral Treatment for HIV/AIDS Patients in Vietnam
  • B. Tran
  • Medicine, Psychology
    PloS one
  • 2012
Strengthening the quality of ART services at the provincial and district levels, gender-specific impact mitigation, and early treatment supports are recommended for further expansion ofART services in Vietnam.
Does duration on antiretroviral therapy determine health-related quality of life in people living with HIV? A cross-sectional study in a regional referral hospital in Kenya
Patients on ART for a relatively longer duration reported poorer HRQoL at the study facility independent of the effect of other therapy-related, clinical, and sociodemographic factors, which may have negative repercussions on the substantial gains made against the HIV scourge.
AIDS treatment and mental health: evidence from Uganda.
Quality of life of people living with HIV and AIDS in Swaziland who are on antiretroviral therapy
The study concluded that PLWHA in Swaziland who are on antiretroviral therapy (ART) are powerless to deal with the above challenges and improve their QOL.
Effect of antiretroviral therapy on patients’ economic well being: five-year follow-up
Results from one of the longest prospective cohorts tracking economic outcomes of HIV treatment in Africa suggest continuous improvement during the first 5 years on treatment, confirming the sustained economic benefits of providing large-scale treatment.
Improved quality of life with immediate versus deferred initiation of antiretroviral therapy in early asymptomatic HIV infection
There were modest but significant improvements in self-assessed QOL among those initiating ART immediately compared to deferring treatment, supporting patient-perceived health benefits of initiating ART as soon as possible after an HIV diagnosis.
Prospective cohort study of the impact of antiretroviral therapy on employment outcomes among HIV clients in Uganda.
Improvements in general health, reduction in the incidence of pain and health interfering with work, as well as improvements in work-related self-efficacy for both groups over time, but significantly more so for the group receiving ART treatment.
Determinants of health-related quality of life in adults living with HIV in Vietnam
The findings highlight the need to improve the health service referral system and enhance psychological and social supports for patients in early stages of HIV infection in Vietnam.


The impact of HIV treatment on risk behaviour in developing countries: A systematic review
The available evidence indicates a significant reduction in risk behaviour associated with ART in developing countries, however, there are few existing studies and the rigor of these studies is weak, so more studies are needed to build an evidence base on which to make programmatic and policy decisions.
Trends and predictors of quality of life among HIV-infected adults taking highly active antiretroviral therapy in rural Uganda
While several clinical, psychosocial and sociodemographic factors predicted QOL at HAART initiation, financial dependence on others was the only remaining predictor after controlling for time on HAART.
Patient Retention in Antiretroviral Therapy Programs in Sub-Saharan Africa: A Systematic Review
Better patient tracing procedures, better understanding of loss to follow-up, and earlier initiation of ART to reduce mortality are needed if retention in ART programs in sub-Saharan Africa is to be improved.
Highly active antiretroviral treatment and health related quality of life in South African adults with human immunodeficiency virus infection: A cross-sectional analytical study
HAART was associated with improved HRQoL in patients enrolled in a public sector treatment program in South Africa and the finding that the EuroQol instrument was sensitive to HAART supports its use in future evaluation of HIV/AIDS care in South Africans.
Year impact of highly active antiretroviral therapy on quality of life of HIV-infected Nigerians
Efforts must be made towards simplifying the therapeutic regimen to reduce the number of daily doses and substitution with treatment combinations and strategies that minimize negative adverse effect to ensure that mortality and morbidity are minimize and quality life optimized.
Impact of antiretroviral therapy on vocational rehabilitation
It is suggested that the provision of free ART by the state can significantly improve the employment status of PLWHA.
Prolongation and quality of life for HIV-infected adults treated with highly active antiretroviral therapy (HAART): a balancing act.
Research findings on treatment and QOL outcomes a decade into the HAART era are reviewed, finding the role of disease progression in eroding quality of life (QOL) erosion in the pre-HAART age is now supplanted by drug toxicities.
Implementation of an Antiretroviral Access Program for HIV-1-Infected Individuals in Resource-Limited Settings: Clinical Results From 4 African Countries
Overall virologic and immunologic responses to HAART in resource-limited African settings can be as good as in Western settings.
Highly active antiretroviral therapy and sexual risk behavior: a meta-analytic review.
In the studies reviewed, HIV-positive patients receiving HAART did not exhibit increased sexual risk behavior, even when therapy achieved an undetectable viral load, and people's beliefs about HAART and viral load may promote unprotected sex and may be amenable to change through prevention messages.
Social support and quality of life over time among adults living with HIV in the HAART era.