Ecological effect of gatifloxacin on the normal human intestinal microflora.

@article{Edlund1999EcologicalEO,
  title={Ecological effect of gatifloxacin on the normal human intestinal microflora.},
  author={Charlotta Edlund and Carl Erik Nord},
  journal={Journal of chemotherapy},
  year={1999},
  volume={11 1},
  pages={50-3}
}
Gatifloxacin, a new broad-spectrum fluoroquinolone, was given in oral doses of 400 mg once daily for 10 days to 18 healthy volunteers, in order to study the impact on the normal intestinal microflora. Fecal samples were collected prior to administration (Day -4 and Day -1), during the administration period (Day 5 and 10) and after withdrawal of administration (Day 12, 16, 22, 30 and 50). In the aerobic intestinal microflora Escherichia coli strains were eliminated or strongly suppressed during… CONTINUE READING

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