Echinosporins as new cell cycle inhibitors and apoptosis inducers from marine-derived Streptomyces albogriseolus.

@article{Cui2007EchinosporinsAN,
  title={Echinosporins as new cell cycle inhibitors and apoptosis inducers from marine-derived Streptomyces albogriseolus.},
  author={Cheng-bin Cui and Hui Liu and Ji Yi Gu and Qian Qun Gu and Baochang Cai and David Y. Zhang and Tian Jiao Zhu},
  journal={Fitoterapia},
  year={2007},
  volume={78 3},
  pages={238-40}
}
Bioassay-guided fractionation of the ethyl acetate extract from the fermentation broth of marine-derived Streptomyces albogriseolus A2002 led to the isolation of echinosporin (1) and 7-deoxyechinosporin (2). Compound 1 inhibited the proliferation of tsFT210, K562 and HCT-15 cancer cells (IC(50) 91.5 microM, 25.1 microM and 247 microM respectively) and 2 showed the same effect on K562 cells (IC(50) 143 microM). Flow cytometric analysis suggested that 1 and 2 exert their anti-proliferative… CONTINUE READING