Echinoside A, a new marine-derived anticancer saponin, targets topoisomerase2alpha by unique interference with its DNA binding and catalytic cycle.

@article{Li2010EchinosideAA,
  title={Echinoside A, a new marine-derived anticancer saponin, targets topoisomerase2alpha by unique interference with its DNA binding and catalytic cycle.},
  author={Mei Li and Z-H Miao and Z Chen and Q. Chen and M Gui and L-P Lin and Pingli Sun and Y-H Yi and Jixin Ding},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2010},
  volume={21 3},
  pages={597-607}
}
BACKGROUND Echinoside A was isolated from sea cucumber. This study demonstrates its anticancer effects and its mechanisms of action. MATERIALS AND METHODS Anticancer effects of echinoside A were evaluated in vitro and in vivo. TUNEL and DNA fragmentation assays were applied to examine its ability to induce apoptosis. A series of biochemical assays were applied to investigate the inhibition of echinoside A on topoisomerase2alpha (Top2alpha). Molecular docking analyses were used to demonstrate… CONTINUE READING