Echinocandin susceptibility testing of Candida spp. Using EUCAST EDef 7.1 and CLSI M27-A3 standard procedures: analysis of the influence of bovine serum albumin supplementation, storage time, and drug lots.

@article{Arendrup2011EchinocandinST,
  title={Echinocandin susceptibility testing of Candida spp. Using EUCAST EDef 7.1 and CLSI M27-A3 standard procedures: analysis of the influence of bovine serum albumin supplementation, storage time, and drug lots.},
  author={Maiken Cavling Arendrup and Juan-Luis Rodriguez-Tudela and Steven Y Park and Guillermo Garc{\'i}a-Effr{\'o}n and G. Delmas and Manuel Cuenca-Estrella and Alicia G{\'o}mez-L{\'o}pez and David Scott Perlin},
  journal={Antimicrobial agents and chemotherapy},
  year={2011},
  volume={55 4},
  pages={1580-7}
}
The MICs of echinocandins against Candida isolates with fks mutations are higher than those for wild-type (WT) isolates. However, the MIC ranges for susceptible and mutant populations overlap or are poorly separated. It was recently reported that a greater separation could be achieved in the presence of serum. To more fully explore this possibility, we compared the performances of the reference microdilution methods by using standard and bovine serum albumin (BSA)-supplemented growth medium… CONTINUE READING

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