Eccentric exercise-induced injuries to contractile and cytoskeletal muscle fibre components.

@article{Fridn2001EccentricEI,
  title={Eccentric exercise-induced injuries to contractile and cytoskeletal muscle fibre components.},
  author={Jan Frid{\'e}n and Richard L. Lieber},
  journal={Acta physiologica Scandinavica},
  year={2001},
  volume={171 3},
  pages={
          321-6
        }
}
Exercise involving lengthening of an activated muscle can cause injury. Recent reports documented the mechanics of exercise-induced muscle injury as well as physiological and cellular events and manifestations of injury. Loss of the cytoskeletal protein desmin and loss of cellular integrity as evidenced by sarcolemmal damage occur early during heavy eccentric exercise. These studies indicate that the earliest events in muscle injury are mechanical in nature, while later events indicate that it… 

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