Ebselen protects against methylmercury-induced inhibition of glutamate uptake by cortical slices from adult mice.

@article{Farina2003EbselenPA,
  title={Ebselen protects against methylmercury-induced inhibition of glutamate uptake by cortical slices from adult mice.},
  author={Marcelo Farina and Marcos Em{\'i}lio Frizzo and F{\'e}lix Alexandre Antunes Soares and F{\'a}bio Duarte Schwalm and Marcelo de Oliveira Dietrich and Gilson Zeni and Jo{\~a}o Batista T Rocha and Diogo Onofre Souza},
  journal={Toxicology letters},
  year={2003},
  volume={144 3},
  pages={351-7}
}
Methylmercury (MeHg) is a highly neurotoxic compound and the inhibition of glutamate uptake by astrocytes has been pointed as an important mechanism involved in MeHg-induced glutamate excitotoxicity. We examined the effect of oral exposure to MeHg (10 and 40 mg/l in drinking water) on glutamate uptake by brain cortical slices of adult mice. Moreover, the possible protective role of ebselen (20 mg/kg, subcutaneously) against MeHg effect was also examined. In addition, it was measured the… CONTINUE READING