Ebselen attenuates oxidative stress-induced apoptosis via the inhibition of the c-Jun N-terminal kinase and activator protein-1 signalling pathway in PC12 cells.

@article{Yoshizumi2002EbselenAO,
  title={Ebselen attenuates oxidative stress-induced apoptosis via the inhibition of the c-Jun N-terminal kinase and activator protein-1 signalling pathway in PC12 cells.},
  author={Masanori Yoshizumi and Toshiaki Kogame and Yuki Suzaki and Yoshiko Fujita and Moe Kyaw and Kazuyoshi Kirima and Keisuke Ishizawa and Koichiro Tsuchiya and Shoji Kagami and Toshiaki Tamaki},
  journal={British journal of pharmacology},
  year={2002},
  volume={136 7},
  pages={1023-32}
}
1: Ebselen (2-phenyl-1,2-benzisoselenazol-3[2H]-one) is a selenoorganic compound exhibiting both glutathione peroxidase activity and antioxidant activity. Although it has been reported that ebselen is effective for oxidative stress-induced neuronal damage both in vivo and clinically, the precise mechanisms of the efficacy have not yet been elucidated. Thus, we hypothesized that ebselen may affect reactive oxygen species-induced mitogen-activated protein (MAP) kinase activation in cultured PC12… CONTINUE READING
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