Ebselen attenuates cochlear damage caused by acoustic trauma.

  title={Ebselen attenuates cochlear damage caused by acoustic trauma.},
  author={Akram Pourbakht and Tatsuya Yamasoba},
  journal={Hearing research},
  volume={181 1-2},
Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one), a seleno-organic compound, mimics glutathione peroxidase and reacts with peroxynitrite. It is reported to protect against gentamicin- and cisplatin-induced ototoxicity. We investigated whether it protects the cochlea from acoustic trauma. Male pigmented guinea pigs (250-300 g) with normal auditory brainstem response (ABR) thresholds were exposed for 5 h to 125 dB sound pressure level octave band noise centered at 4 kHz. One hour before and 18 h… CONTINUE READING
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