Ebp1 association with nucleophosmin/B23 is essential for regulating cell proliferation and suppressing apoptosis.

@article{Okada2007Ebp1AW,
  title={Ebp1 association with nucleophosmin/B23 is essential for regulating cell proliferation and suppressing apoptosis.},
  author={Masashi Okada and S U Jang and Keqiang Ye},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 50},
  pages={36744-54}
}
Ebp1 and NPM/B23 are essential for cell proliferation and survival. Ebp1 possesses p42 and p48 isoforms. Whereas p42 exclusively resides in the cytoplasm, p48 localizes in both the cytoplasm and the nucleolus. Here, we show that Ebp1 forms a complex with B23, and this complex plays a critical role in cell proliferation and survival. p42 specifically associates with B23 upon epidermal growth factor stimulation, while p48 constantly binds B23. Moreover, Ser360 phosphorylation in p42, but not p48… CONTINUE READING