Ebp1 Sumoylation, Regulated by TLS/FUS E3 Ligase, Is Required for its Anti-proliferative Activity

@inproceedings{Oh2010Ebp1SR,
  title={Ebp1 Sumoylation, Regulated by TLS/FUS E3 Ligase, Is Required for its Anti-proliferative Activity},
  author={Sang-Muk Oh and Zhixue Liu and Masashi Okada and S U Jang and Xia Liu and Chi Bun Chan and Hongbo Robert Luo and Keqiang Ye},
  booktitle={Oncogene},
  year={2010}
}
Ebp1, an ErbB3 receptor-binding protein, inhibits cell proliferation and acts as a putative tumor suppressor. Ebp1 translocates into the nucleus and functions as a transcription co-repressor for E2F-1. Here, we show that Ebp1 p42 isoform can be sumoylated on both K93 and K298 residues, which mediate its nuclear translocation and are required for its anti-proliferative activity. We find that translocation in liposarcoma (TLS)/FUS, an RNA-binding nuclear protein that is involved in pre-mRNA… CONTINUE READING

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