Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression

@article{Kimberlin2009EbolavirusVU,
  title={Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression},
  author={C. Kimberlin and Z. Bornholdt and S. Li and Virgil L. Woods and I. MacRae and E. O. Saphire},
  journal={Proceedings of the National Academy of Sciences},
  year={2009},
  volume={107},
  pages={314 - 319}
}
Ebolavirus causes a severe hemorrhagic fever and is divided into five distinct species, of which Reston ebolavirus is uniquely nonpathogenic to humans. Disease caused by ebolavirus is marked by early immunosuppression of innate immune signaling events, involving silencing and sequestration of double-stranded RNA (dsRNA) by the viral protein VP35. Here we present unbound and dsRNA-bound crystal structures of the dsRNA-binding domain of Reston ebolavirus VP35. The structures show that VP35 forms… Expand
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