Ebolavirus VP24 binding to karyopherins is required for inhibition of interferon signaling.

@article{Mateo2010EbolavirusVB,
  title={Ebolavirus VP24 binding to karyopherins is required for inhibition of interferon signaling.},
  author={Mathieu Mateo and St. Patrick Reid and Lawrence W. Leung and Christopher F Basler and Viktor E. Volchkov},
  journal={Journal of virology},
  year={2010},
  volume={84 2},
  pages={1169-75}
}
The Ebolavirus VP24 protein counteracts alpha/beta interferon (IFN-alpha/beta) and IFN-gamma signaling by blocking the nuclear accumulation of tyrosine-phosphorylated STAT1 (PY-STAT1). According to the proposed model, VP24 binding to members of the NPI-1 subfamily of karyopherin alpha (KPNalpha) nuclear localization signal receptors prevents their binding to PY-STAT1, thereby preventing PY-STAT1 nuclear accumulation. This study now identifies two domains of VP24 required for inhibition of IFN… CONTINUE READING
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