Ebolavirus Is Internalized into Host Cells via Macropinocytosis in a Viral Glycoprotein-Dependent Manner

@inproceedings{Nanbo2010EbolavirusII,
  title={Ebolavirus Is Internalized into Host Cells via Macropinocytosis in a Viral Glycoprotein-Dependent Manner},
  author={Asuka Nanbo and Masaki Imai and Shinji Watanabe and Takeshi Noda and Kei S Takahashi and Gabriele Neumann and Peter Halfmann and Yoshihiro Kawaoka},
  booktitle={PLoS pathogens},
  year={2010}
}
Ebolavirus (EBOV) is an enveloped, single-stranded, negative-sense RNA virus that causes severe hemorrhagic fever with mortality rates of up to 90% in humans and nonhuman primates. Previous studies suggest roles for clathrin- or caveolae-mediated endocytosis in EBOV entry; however, ebolavirus virions are long, filamentous particles that are larger than the plasma membrane invaginations that characterize clathrin- or caveolae-mediated endocytosis. The mechanism of EBOV entry remains, therefore… CONTINUE READING

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