Ebola virus requires a host scramblase for externalization of phosphatidylserine on the surface of viral particles

@inproceedings{Nanbo2018EbolaVR,
  title={Ebola virus requires a host scramblase for externalization of phosphatidylserine on the surface of viral particles},
  author={Asuka Nanbo and Junki Maruyama and Masaki Imai and Michiko Ujie and Yoichiro Fujioka and Shinya Nishide and Ayato Takada and Yusuke Ohba and Yoshihiro Kawaoka},
  booktitle={PLoS pathogens},
  year={2018}
}
Cell surface receptors for phosphatidylserine contribute to the entry of Ebola virus (EBOV) particles, indicating that the presence of phosphatidylserine in the envelope of EBOV is important for the internalization of EBOV particles. Phosphatidylserine is typically distributed in the inner layer of the plasma membrane in normal cells. Progeny virions bud from the plasma membrane of infected cells, suggesting that phosphatidylserine is likely flipped to the outer leaflet of the plasma membrane… CONTINUE READING

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